Journal article
Latent infection with cytomegalovirus is associated with poor memory CD4 responses to influenza a core proteins in the elderly
E Derhovanessian, AB Maier, K Hähnel, JE McElhaney, EP Slagboom, G Pawelec
Journal of Immunology | AMER ASSOC IMMUNOLOGISTS | Published : 2014
Abstract
Influenza remains a major pathogen in older people. Infection with CMV and the accumulation of late-differentiated T cells associated with it have been implicated in poor Ab responsiveness to influenza vaccination in the elderly, most of whom are CMV positive. However, whether CMV infection also affects memory T cell responses to influenza remains unknown. To investigate this, we assessed T cell responses to influenza A matrix protein and nucleoprotein ex vivo in 166 Dutch individuals (mean age 62.2 y, range 42-82) and validated the results in a second cohort from North America (mean age 73.1 y, range 65-81, n = 28).We found that less than half of the CMV-infected older subjects mounted a CD..
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Funding Acknowledgements
This work was supported by European Commission (Grant FP6 036894, "LifeSpan"; Grant FP7 259679, "IDEAL"), Grant DFG-PA 361/14-1, and the Bundesminsterium fur Bildung und Forschung project "Gerontoshield" (Grant 0315890F). The Leiden Longevity Study was funded by the Innovation Oriented Research Program on Genomics (SenterNovem; Grants IGE01014 and IGE5007), the Centre for Medical Systems Biology, and the Netherlands Genomics Initiative/Netherlands Organization for Scientific Research (Grants 05040202 and 050-060-810). The study in Vancouver, BC, Canada, was sponsored by the Canadian Institutes of Health Research (Grant MOP-89729 to J.E.M.).