Journal article
MicroRNA-663 induction upon oxidative stress in cultured human fibroblasts depends on the chronological age of the donor
MEC Waaijer, M Wieser, R Grillari-Voglauer, D Van Heemst, J Grillari, AB Maier
Biogerontology | SPRINGER | Published : 2014
Abstract
MicroRNAs, regulators of messenger RNA translation, have been observed to influence many physiological processes, amongst them the process of aging. Higher levels of microRNA-663 (miR-663) have previously been observed in human dermal fibroblasts subject to both replicative and stress-induced senescence compared to early passage cells. Also, higher levels of miR-663 have been found in memory T-cells and in human fibroblasts derived from older donors compared to younger donors. In previous studies we observed that dermal fibroblasts from donors of different chronological and biological age respond differentially to oxidative stress measured by markers of cellular senescence and apoptosis. In ..
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Awarded by Austrian Federal Ministry of Economy, Family and Youth
Funding Acknowledgements
We would like to thank Corine de Koning-Treurniet, Joke Blom and Pim Dekker for their work in the laboratory. This work was supported by the Austrian Science Fund [P 24498-B20]; Genome Research Austria GEN-AU [Project 820982 "Non-coding RNAs''], grants by the Herzfelder'sche Familienstiftung to RGV and CE.R.I.E.S to JG, SenterNovem, IGE01014 and IGE5007, NGI/NWO; 05040202 and 050-060-810. The financial support by the Austrian Federal Ministry of Economy, Family and Youth and the National Foundation for Research, Technology and Development is gratefully acknowledged as well as financial support by Chanel Research and Technology.