Renal function in familial longevity: the Leiden Longevity Study
Moniek CM de Goeij, Nynke Halbesma, Friedo W Dekker, Carolien A Wijsman, Diana van Heemst, Andrea B Maier, Simon P Mooijaart, P Eline Slagboom, Rudi GJ Westendorp, Anton JM de Craen
Experimental Gerontology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2014
Studying renal function in subjects with a familial propensity for longevity may provide insight in (un)known mechanisms that determine the age-related decline in renal function of normal subjects. In the Leiden Longevity Study, middle-aged offspring of non-agenarian siblings and their partners as environmentally matched controls were included. Information was collected on lifestyle, medical history, medication use, and a non-fasting blood sample was drawn. Renal function (estimated glomerular filtration rate, eGFR) was assessed with the Chronic Kidney Disease epidemiology collaboration (CKD-EPI) formula. Linear mixed models were used to account for familial dependencies within the offspring..View full abstract
Awarded by Innovation Oriented Research Program on Genomics (SenterNovem)
Awarded by Netherlands Genomics Initiative/Netherlands Organization for Scientific Research (NGI/NWO)
This study was funded by the Innovation Oriented Research Program on Genomics (SenterNovem; IGE01014 and IGE5007) and The Netherlands Genomics Initiative/Netherlands Organization for Scientific Research (NGI/NWO; 05040202 and 050-060-810 NCHA). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.