Lower proportion of na < ve peripheral CD8 T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people
Evelyna Derhovanessian, Andrea B Maier, Karin Haehnel, Henning Zelba, Anton JM de Craen, Helene Roelofs, Eline P Slagboom, Rudi GJ Westendorp, Graham Pawelec
AGE | SPRINGER | Published : 2013
Awarded by European Commission
Awarded by DFG-PA
Awarded by BMBF
Awarded by Netherlands Genomics Initiative/Netherlands Organization for scientific research [NGI/NWO; Netherlands Consortium for Healthy Aging (NCHA)]
We would like to thank Prof. Hans-Peter Pircher (University of Freiburg) for providing the anti-KRLG1 antibody and Lilly Oettinger for antibody titration and flow cytometry quality controls. This work was supported by the European Commission (FP6 036894, "LifeSpan"; FP7 259679 "IDEAL"), DFG-PA 361/14-1, and the BMBF project "Gerontoshield" (0315890F). The Leiden 85+ study was funded by the Program Translational Research of the Netherlands organization for health research and development, the Leiden University Fund, and by an unrestricted grant from the Netherlands Organization of Scientific Research (ZonMw), the Ministry of Health, Welfare and Sports, and the Netherlands Genomics Initiative/Netherlands Organization for scientific research [NGI/NWO; 05040202 and 050-060-810 Netherlands Consortium for Healthy Aging (NCHA)].