Journal article

Increased Plin2 Expression in Human Skeletal Muscle Is Associated with Sarcopenia and Muscle Weakness

Maria Conte, Francesco Vasuri, Giovanni Trisolino, Elena Bellavista, Aurelia Santoro, Alessio Degiovanni, Ermanno Martucci, Antonia D'Errico-Grigioni, Daniela Caporossi, Miriam Capri, Andrea B Maier, Olivier Seynnes, Laura Barberi, Antonio Musaro, Marco V Narici, Claudio Franceschi, Stefano Salvioli



Human aging is associated with a progressive loss of muscle mass and strength and a concomitant fat accumulation in form of inter-muscular adipose tissue, causing skeletal muscle function decline and immobilization. Fat accumulation can also occur as intra-muscular triglycerides (IMTG) deposition in lipid droplets, which are associated with perilipin proteins, such as Perilipin2 (Plin2). It is not known whether Plin2 expression changes with age and if this has consequences on muscle mass and strength. We studied the expression of Plin2 in the vastus lateralis (VL) muscle of both healthy subjects and patients affected by lower limb mobility limitation of different age. We found that Plin2 exp..

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Awarded by European Union

Awarded by MRC

Awarded by Medical Research Council

Funding Acknowledgements

The research leading to these results has received funding from the European Union's Seventh Framework Programme (FP7/2007-2011) under grant agreement no 223576 (MYOAGE) to CF, MN and AM. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.