Journal article
Ambulant 24-h glucose rhythms mark calendar and biological age in apparently healthy individuals
CA Wijsman, D Van Heemst, ES Hoogeveen, PE Slagboom, AB Maier, AJM De Craen, F Van Der Ouderaa, H Pijl, RGJ Westendorp, SP Mooijaart
Aging Cell | WILEY | Published : 2013
DOI: 10.1111/acel.12042
Abstract
Glucose metabolism marks health and disease and is causally inferred in the aging process. Ambulant continuous glucose monitoring provides 24-h glucose rhythms under daily life conditions. We aimed to describe ambulant 24-h glucose rhythms measured under daily life condition in relation to calendar and biological age in apparently healthy individuals. In the general population and families with propensity for longevity, we studied parameters from 24-h glucose rhythms; glucose levels; and its variability, obtained by continuous glucose monitoring. Participants were 21 young (aged 22-37 years), 37 middle-aged (aged 44-72 years) individuals from the general population, and 26 middle-aged (aged ..
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Awarded by European Commission
Funding Acknowledgements
We thank all study participants for their contribution. The study was supported by the Innovation Oriented research Program on Genomics (SenterNovem; IGE01014 and IGE5007), the Netherlands Genomics Initiative/Netherlands Organization for scientific research (NGI/NWO; 05040202 and 050-060-810), and the EC funded project Switchbox (FP7, Health-F2-2010-259772). The funders had no role in the design, performance or analyses of the study, or in the drafting of the manuscript.