Journal article
Familial Longevity Is Marked by Better Cognitive Performance at Middle Age: The Leiden Longevity Study
M Stijntjes, AJM de Craen, D van Heemst, CGM Meskers, MA van Buchem, RGJ Westendorp, PE Slagboom, AB Maier
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2013
Open access
Abstract
Background: Decline in cognitive performance is a highly prevalent health condition in elderly. We studied whether offspring of nonagenarian siblings with a familial history of longevity, perform better on cognitive tests compared to their partners as controls. This is relevant since it could provide insights into determinants underlying decline in cognitive performance. Methods: Cross-sectional analysis within the longitudinal cohort of the Leiden Longevity Study consisting of middle-aged offspring of nonagenarian siblings together with their partners (n = 500, mean age (SD) 66.3 (6.1) and 65.7 (7.2) years, respectively) as controls. Memory function, attention and processing speed were test..
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Awarded by European Commission
Funding Acknowledgements
Funding provided by The Leiden Longevity Study was funded by the Innovation Oriented research Program on Genomics (SenterNovem; www.agentschapnl.nl; IGE01014 and IGE5007), the Centre for Medical Systems Biology (CMSB; www.cmsb.nl), the Netherlands Genomics Initiative/Netherlands Organization for scientific research (NGI/NWO; www.genomics.nl/www.nwo.nl; 05040202 and 050-060-810 Netherlands Consortium for Healthy Aging (NCHA; www.healty-ageing.nl)), the European Commission funded project Myoage (FP7, HEALTH-2007-2.4.5-10; www.myoage.eu) and Switchbox (FP7, Health-F2-2010-259772; www.switchbox-online.eu). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.