Journal article
Gene expression analysis of mTOR pathway: Association with human longevity
WM Passtoors, M Beekman, J Deelen, R van der Breggen, AB Maier, B Guigas, E Derhovanessian, D van Heemst, AJM de Craen, DA Gunn, G Pawelec, PE Slagboom
Aging Cell | WILEY | Published : 2013
DOI: 10.1111/acel.12015
Abstract
mTOR signalling is implicated in the development of disease and in lifespan extension in model organisms. This pathway has been associated with human diseases such as diabetes and cancer, but has not been investigated for its impact on longevity per se. Here, we investigated whether transcriptional variation within the mTOR pathway is associated with human longevity using whole-blood samples from the Leiden Longevity Study. This is a unique cohort of Dutch families with extended survival across generations, decreased morbidity and beneficial metabolic profiles in middle-age. By comparing mRNA levels of nonagenarians and middle-aged controls, the mTOR signalling gene set was found to associat..
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Awarded by European Commission
Funding Acknowledgements
We thank all participants of the Leiden Longevity Study. The research leading to these results has received funding from the European Union's Seventh Framework Programme (FP7/2007-2011) under grant agreement no. 259679. This study was supported by a grant from the Innovation-Oriented Research Program on Genomics (SenterNovem IGE05007), the Centre for Medical Systems Biology, the Netherlands Consortium for Healthy Ageing (Grant 050-060-810), all in the framework of the Netherlands Genomics Initiative, the Netherlands Organization for Scientific Research (NWO) and by Unilever Colworth. David A. Gunn is employed by Unilever PLC and involved in the design, data collection and analysis as well as the decision to publish.