Journal article
High serum glucose levels are associated with a higher perceived age
R Noordam, DA Gunn, CC Tomlin, AB Maier, SP Mooijaart, PE Slagboom, RGJ Westendorp, AJM De Craen, D Van Heemst
Age | SPRINGER | Published : 2013
Abstract
Estimating perceived age by facial photographs is a good estimate of health in elderly populations. Previously, we showed that familial longevity is marked by a more beneficial glucose metabolism already at middle age. As glucose is also related to skin aging, this study aimed to investigate the association between glucose metabolism and perceived age. Perceived age was assessed using facial photographs and non-fasted glucose and insulin were measured in 602 subjects from the Leiden Longevity Study. Non-diabetic subjects (n = 569) were divided in three strata according to their glucose levels, and diabetic subjects (n = 33; as a proxy of long-term hyperglycemic exposure) were included as a f..
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Awarded by Centre for Medical Systems Biology
Funding Acknowledgements
We would like to thank all participants, the secretary staff (Meriam H.G.F. van der Star and Ellen H.M. Bemer-Oorschot), and the research nurse (Corrie Groenendijk) for their valuable contribution to this study. We would also like to thank Chris Griffiths, Sharon Catt, Tamara Griffiths, and Stephanie Ogden for generating the photo-damage scores and Peter Murray for calculating the mean perceived ages. This study was funded by the Innovation Oriented Research Program on Genomics (SenterNovem; IGE01014 and IGE5007), the Centre for Medical Systems Biology (CMSB), the Netherlands Genomics Initiative/Netherlands Organization for scientific research (NGI/NWO; 05040202 and 050-060-810.NCHA), Unilever PLC, and the EU-funded Network of Excellence Lifespan (FP6 036894). P. Eline Slagboom is supported by an unrestricted grant from the Netherlands Genomics Initiative (NCHA 050-060-810).