Journal article
The effect of chronological age on the inflammatory response of human fibroblasts
J Wolf, B Weinberger, CR Arnold, AB Maier, RGJ Westendorp, B Grubeck-Loebenstein
Experimental Gerontology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2012
Abstract
The immune system undergoes profound age-related changes, including a gradual increase in the production and circulation of proinflammatory cytokines. Despite the known capacity of fibroblasts to produce cytokines, little is known so far about the inflammatory response of fibroblasts to cellular stress such as viral and/or bacterial infection in the context of aging. Therefore the aim of this study was to analyze the levels of IL6 and IL8 secretion in supernatants of human skin fibroblasts from young and elderly persons. Cytokine and chemokine secretion was analyzed before and after in vitro infection of the cells with Cytomegalovirus (CMV) and/or stimulation with Lipopolysaccharide (LPS). T..
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Awarded by Austrian Science Fund
Funding Acknowledgements
This work has been supported by and carried out within the EU funded Network of Excellence LifeSpan (project EUPO134) and the Austrian Science Fund (project S9308-B05). We want to thank Brigitte Jenewein and Michael Keller for the excellent technical assistance.