Journal article
Early-life environment influencing susceptibility to cytomegalovirus infection: Evidence from the Leiden Longevity Study and the Longitudinal Study of Aging Danish Twins
LH Mortensen, AB Maier, PE Slagbom, G Pawelec, E Derhovanessian, I Petersen, G Jahn, RGJ Westendorp, K Christensen
Epidemiology and Infection | CAMBRIDGE UNIV PRESS | Published : 2012
Abstract
Human cytomegalovirus (CMV) is a common herpesvirus establishing lifelong persisting infection, which has been implicated in immunosenescence and mortality in the elderly. Little is known about how and when susceptibility to CMV infection is determined. We measured CMV seroprevalence in two genetically informative cohorts. From the Leiden Longevity Study (LLS) we selected long-lived sib-pairs (n=844) and their middle-aged offspring and the offspring's partners (n=1452). From the Longitudinal Study of Aging Danish Twins (LSADT) 604 (302 pairs) same-sex monozygotic (MZ) and dizygotic (DZ) twins aged 73-94 years were included (n=302 pairs). Offspring of the long-lived LLS participants had signi..
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Funding Acknowledgements
This study was partially supported by the LifeSpan Network of Excellence, which was funded by the European Union 6th Framework Programme. The first and corresponding author is the guarantor for the integrity of the article as a whole.