Journal article
Familial longevity is marked by lower diurnal salivary cortisol levels: The Leiden longevity study
R Noordam, SWM Jansen, AA Akintola, NYL Oei, AB Maier, H Pijl, PE Slagboom, RGJ Westendorp, J van der Grond, AJM de Craen, D van Heemst
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2012
Abstract
Background: Reported findings are inconsistent whether hypothalamic-pituitary-adrenal (HPA) signaling becomes hyperactive with increasing age, resulting in increasing levels of cortisol. Our previous research strongly suggests that offspring from long-lived families are biologically younger. In this study we assessed whether these offspring have a lower HPA axis activity, as measured by lower levels of cortisol and higher cortisol feedback sensitivity. Methods: Salivary cortisol levels were measured at four time points within the first hour upon awakening and at two time points in the evening in a cohort comprising 149 offspring and 154 partners from the Leiden Longevity Study. A dexamethaso..
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Awarded by European Commission
Funding Acknowledgements
This study was funded by the European Commission funded project Switchbox (FP7, Health-F2-2010-259772), the Innovation Oriented research Program on Genomics (SenterNovem; IGE01014 and IGE5007), the Centre for Medical Systems Biology, the Netherlands Genomics Initiative/Netherlands Organization for scientific research (NGI/NWO; 05040202 and 050-060-810. NCHA). PES is supported by an unrestricted grant from the Netherlands Genomics Initiative (NCHA 050-060-810). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.