Relation between replicative senescence of human fibroblasts and life history characteristics
Andrea B Maier, Rudi GJ Westendorp
Ageing Research Reviews | ELSEVIER IRELAND LTD | Published : 2009
Replicative ageing of fibroblasts in vitro has often been used as a model for organismal ageing. The general assumption that the ageing process is mirrored by cellular senescence in vitro is based on lower replicative capacity of human fibroblasts from patients with accelerated ageing syndromes, patients with age related diseases such as diabetes mellitus, and donors of higher chronological age, but these inverse relations have not been reported unequivocally. Therefore, we have performed a formal review on the replicative capacity of fibroblasts from patients suffering from accelerated ageing syndromes, age related diseases and donor age. Some 13 studies including 79 patients with accelerat..View full abstract
Awarded by Innovation Oriented Research Program on Genomics
Awarded by Netherlands Genomics Initiative/Netherlands Organization for Scientific Research (NGI/NWO)
Awarded by EU
Supported by the Innovation Oriented Research Program on Genomics (SenterNovem; IGE01014 and IGE5007), the Centre for Medical Systems Biology (CMSB), the Netherlands Genomics Initiative/Netherlands Organization for Scientific Research (NGI/NWO; 05040202) and the EU Funded Network of Excellence Lifespan (FP6 036894). We thank Ton de Craen for expert statistical assistance.