Proton magnetic resonance spectroscopy shows lower intramyocellular lipid accumulation in middle-aged subjects predisposed to familial longevity
CA Wijsman, AM van Opstal, HE Kan, AB Maier, RGJ Westendorp, PE Slagboom, AG Webb, SP Mooijaart, D van Heemst
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | AMER PHYSIOLOGICAL SOC | Published : 2012
Families predisposed to longevity show enhanced glucose tolerance and skeletal muscle insulin sensitivity compared with controls, independent of body composition and physical activity. Intramyocellular lipid (IMCL) accumulation in skeletal muscle has been associated with insulin resistance. Here, we assessed whether subjects enriched for familial longevity have lower IMCL levels. We determined IMCL levels in 48 subjects from the Leiden Longevity Study, comprising 24 offspring of nonagenarian siblings and 24 partners thereof as control subjects. IMCL levels were assessed noninvasively using short echo time proton magnetic resonance spectroscopy ((1)H-MRS) of the tibialis anterior muscle with ..View full abstract
Awarded by Innovation Oriented Research Program on Genomics
Awarded by Netherlands Genomics Initiative/Netherlands Organization for Scientific Research (NGI/ NWO)
The study was supported by the Innovation Oriented Research Program on Genomics (SenterNovem; IGE01014 and IGE5007) and The Netherlands Genomics Initiative/Netherlands Organization for Scientific Research (NGI/ NWO; 05040202 and 050-060-810).