Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4( ) and CD8( ) T-cells in humans
Evelyna Derhovanessian, Andrea B Maier, Karin Hahnel, Robert Beck, Anton JM de Craen, Eline P Slagboom, Rudi GJ Westendorp, Graham Pawelec
Journal of General Virology | SOC GENERAL MICROBIOLOGY | Published : 2011
Human cytomegalovirus (CMV) establishes persistent, usually asymptomatic, infection in healthy people. Because CMV infection is associated with the presence of lower proportions of peripheral naïve CD8+ T-cells and a higher fraction of late-differentiated CD8+ cells, commonly taken as biomarkers of age-associated compromised adaptive immunity ('immunosenescence'), we asked whether chronic exposure to any persistent virus mediates these effects. Herpes simplex virus (HSV) is also a widespread herpesvirus that establishes lifelong persistence, but, unlike CMV, its impact on the distribution of T-cell subsets has not been established. Here, we analysed T-cell subsets in 93 healthy people aged 4..View full abstract
Awarded by European Union
Awarded by Innovation Oriented Research Program on Genomics (SenterNovem)
Awarded by Netherlands Genomics Initiative/Netherlands Organization for Scientific Research
This work was supported by the European Union-funded Network of Excellence LifeSpan (FP6 036894), DFG-PA 361/14-1 and DFG-PA 361/11-1. The Leiden Longevity Study was funded by the Innovation Oriented Research Program on Genomics (SenterNovem; IGE01014 and IGE5007), the Centre for Medical Systems Biology and the Netherlands Genomics Initiative/Netherlands Organization for Scientific Research (05040202 and 050-060-810 NCHA). We would like to thank Professor Hans-Peter Pircher for providing the anti-KRLG-1 antibody, Lilly Oettinger for antibody titration and flow cytometry quality controls and Alexander Strik for isolation of PBMCs.