C-reactive protein and glucose regulation in familial longevity
Maarten P Rozing, Simon P Mooijaart, Marian Beekman, Carolien A Wijsman, Andrea B Maier, Andrzej Bartke, Rudi GJ Westendorp, Eline P Slagboom, Diana van Heemst
Age | SPRINGER | Published : 2011
Earlier, we showed that the offspring from exceptionally long-lived families have a more favorable glucose metabolism when compared with controls. As chronic low-grade inflammation has been regarded as a strong risk factor for insulin resistance, we evaluated if and to what extent the favorable glucose metabolism in offspring from long-lived families could be explained by differences in subclinical inflammation, as estimated from circulating levels of C-reactive protein. We found no difference between the two groups in C-reactive protein levels or in the distribution of C-reactive protein haplotypes. However, among controls higher levels of C-reactive protein were related to higher glucose l..View full abstract
Awarded by Innovation Oriented Research Program on Genomics (SenterNovem)
Awarded by Netherlands Genomics Initiative/Netherlands Organization for scientific research (NGI/NWO)
Awarded by EU
We thank Stella Trompet for her valuable assistance with the statistical analyses of the data. This study was supported by the Innovation Oriented Research Program on Genomics (SenterNovem; IGE01014 and IGE5007), the Centre for Medical Systems Biology (CMSB), the Netherlands Genomics Initiative/Netherlands Organization for scientific research (NGI/NWO; 05040202 and 050-060-810 (NCHA)), and the EU funded Network of Excellence Lifespan (FP6 036894).