Stress-induced responses of human skin fibroblasts in vitro reflect human longevity
Pim Dekker, Andrea B Maier, Diana van Heemst, Corine de Koning-Treurniet, Joke Blom, Roeland W Dirks, Hans J Tanke, Rudi GJ Westendorp
Aging Cell | WILEY-BLACKWELL PUBLISHING, INC | Published : 2009
Awarded by Innovation Oriented research Program on Genomics
Awarded by Netherlands Genomics Initiative/Netherlands Organization for scientific research
Awarded by EU
Awarded by Netherlands Genomics Initiative
This work was funded by the Innovation Oriented research Program on Genomics (SenterNovem; IGE01014 and IGE5007), the Netherlands Genomics Initiative/Netherlands Organization for scientific research (NGI/NWO; 05040202 and 050-060-810) and the EU funded Network of Excellence Lifespan (FP6 036894). Prof. Westendorp is supported by an unrestricted grant from the Netherlands Genomics Initiative (NCHA 050-060-810). The authors thank Judith Campisi and Arturo Orjalo for sharing their experience with the use of rotenone as senescence-inducing agent, Gerard Noppe for his contribution in setting up the flow cytometric SA-beta-gal procedure and Ton de Craen for his expert statistical assistance.