Journal article

Circulating levels of IGF1 are associated with muscle strength in middle-aged- and oldest-old women

Diana G Taekema, Carolina HY Ling, Gerard Jan Blauw, Carel G Meskers, Rudi GJ Westendorp, Anton JM de Craen, Andrea B Maier

European Journal of Endocrinology | BIOSCIENTIFICA LTD | Published : 2011

Abstract

OBJECTIVE: In aging populations, poor handgrip strength has been associated with physical disability and mortality. IGF1 is an important mediator of muscle growth and regeneration affecting muscle function. We studied the relationship between circulating levels of IGF1, its binding protein 3 (IGFBP3), and handgrip strength and physical performance in middle-aged- and oldest-old subjects. DESIGN: Cross-sectional analysis in two different cohorts composed of middle-aged- (n = 672, mean 63.9 ± 6.7 years) and oldest-old subjects (n = 272, all 89 years). METHODS: Handgrip strength, functional performance and ability, and serum levels of IGF1 and IGFBP3 were measured in all subjects and analyzed b..

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Grants

Awarded by Netherlands Genomics Initiative/Netherlands Organization for scientific research (NGI/NWO), Netherlands Consortium for Healthy Aging


Awarded by seventh framework program MYOAGE


Funding Acknowledgements

This study was supported by an unrestricted grant from The Netherlands Organization of Scientific Research (ZonMw), the Ministry of Health, Welfare and Sports, The Netherlands Genomics Initiative/Netherlands Organization for scientific research (NGI/NWO; 05040202 and 050-060-810 Netherlands Consortium for Healthy Aging (NCHA)) and the seventh framework program MYOAGE (HEALTH-2007-2.4.5-10).