Histological & extended clinical outcomes after ABO-Incompatible renal transplantation without splenectomy or rituximab

Abstract

Background. Excellent short-termresults have been reported in ABO-incompatible (ABOi) renal transplant recipientsmanaged solely with antibody removal and conventional immunosuppression. However, long-term clinical outcomes with this regimen and predictive information from protocol biopsies are lacking.Methods.We compared outcome data in ABOi and ABO-compatible (ABOc) recipients receiving this regimen approximately 4 years posttransplant, and histology from biopsies approximately 12 months posttransplant. Results. Patient and graft survivals among 54 ABOi recipients were 98.1% and 90.7%, respectively, at 4 years. Graft function was similar between ABOi (creatinine, 140.3 μmol/L) and ABOc reci..