Journal article

Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activation

Liyen Loh, Zhongfang Wang, Sneha Sant, Marios Koutsakos, Sinthujan Jegaskanda, Alexandra J Corbett, Ligong Liu, David P Fairlie, Jane Crowe, Jamie Rossjohn, Jianqing Xu, Peter C Doherty, James McCluskey, Katherine Kedzierska

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | NATL ACAD SCIENCES | Published : 2016

DOI: 10.1073/pnas.1610750113

University of Melbourne Researchers

Alexandra Corbett Author Microbiology and Immunology

Zhongfang Wang Author Microbiology and Immunology

James McCluskey Author

Liyen Loh Author Microbiology and Immunology

Jamie Rossjohn Author Microbiology and Immunology

Related Projects (6)

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The development of better ways to prevent and treat influenza infection will be a major step forward in lessening the impact of the virus in..

Limiting The Impact Of Influenza

The development of better ways to prevent and treat influenza infection will be a major step forward in lessening the impact of the virus in..

Limiting The Impact Of Influenza

The development of better ways to prevent and treat influenza infection will be a major step forward in lessening the impact of the virus in..

Limiting The Impact Of Influenza

The development of better ways to prevent and treat influenza infection will be a major step forward in lessening the impact of the virus in..

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The development of better ways to prevent and treat influenza infection will be a major step forward in lessening the impact of the virus in..

Grants

Awarded by National Health and Medical Research Council Program (NHMRC)

Funding Acknowledgements

We thank Andrew Brooks for insightful discussions; Ted Hansen for the alpha-MR1-26.5 blocking reagent; and Thakshila Amarasena, Sheilajen Alcantara, and Bernie McCudden for collecting blood. We thank all donors for donating blood for this study. This work was supported by National Health and Medical Research Council Program (NHMRC) Grant 1071916 (to P.C.D. and K.K.). L. Loh and S.J. were supported by an NHMRC C. J. Martin fellowship. Z.W. was supported by an NHMRC Australia-China exchange fellowship. K.K. is an NHMRC Senior Research Fellow. J.R. is an NHMRC Australia Fellow (AF50). D.P.F. is an NHMRC Senior Principal Research Fellow (1027369). S.S. is supported by a Victoria-India Doctoral Scholarship and a Melbourne International Fee Remission Scholarship (MIFRS). M.K. is supported by a Melbourne International Research Scholarship and an MIFRS.

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Keywords

Science & Technology - Other Topics

Lymphocyte Activation

Hypercytokinemia

Immunity, Mucosal

Nk Cell Lectin-Like Receptor Subfamily B

Gene Expression

Multidisciplinary Sciences

Virus-Infection

Science & Technology

Coculture Techniques

Influenza, Human

Influenza a Virus, H7n9 Subtype

Receptor Heterogeneity

Rapid Differentiation

Pneumonia, Viral

Killer Cells, Natural

Signal Transduction

Interferon-Gamma

Immunophenotyping

Dendritic Cells

Mucosal-Associated Invariant T Cells

Survival Analysis

Influenza Virus

Leukocytes, Mononuclear

Vitamin-B Metabolites

Cell Communication

Immunity, Innate