Occupational exposures to solvents and lead as risk factors foralzheimer’s disease: A collaborativere-analysis of case-control studies

Abstract

A meta-analysis, involving the secondary analysis of original data from 11 case-control studies of Alzheimer’s disease, is presented for occupational exposures to solvents and lead. Three studies had data on occupational exposure to solvents. Among cases, 21.3% were reported to have been exposed; among controls, this figure was comparable(20.9%). This yielded a pooled matched relative risk of 0.76 (95% Cl: 0.47-1.23). Four studies had data on exposure tolead. Exposure frequencies were 6.1% in cases and 8.3% in controls. This resulted in a pooled matched relative risk of0.71 (95% Cl: 0.36-1.41). The meta-analysis was particularly useful in validating negative results from individual studies a..