Maternal age and alzheimer’s disease: A collaborative re-analysisof case-control studies

Abstract

To investigate the possible association between Alzheimer’s disease and late maternal age at index birth, we conducted a collaborative re-analysis of existing case-control data sets. Of the 11 studies participating in the EURODEM project, four were included in the analyses regarding maternal age. In all four studies, cases were matched to controlsby age and gender, and only population controls were considered. Analyses were conducted on the individual datasets, on the pooled sample, and on subgroups defined by gender, age at onset, and familial aggregation of dementia.Maternal age of 40 years and over was found to be suggestively associated with a higher risk of Alzheimer’s disease(overall r..