Emergence of endemic MLST non-typeable vancomycin-resistant Enterococcus faecium

Glen P Carter; Andrew H Buultjens; Susan A Ballard; Sarah L Baines; Takehiro Tomita; Janet Strachan; Paul DR Johnson; John K Ferguson; Torsten Seemann; Timothy P Stinear; Benjamin P Howden

Journal article

Emergence of endemic MLST non-typeable vancomycin-resistant Enterococcus faecium

Glen P Carter, Andrew H Buultjens, Susan A Ballard, Sarah L Baines, Takehiro Tomita, Janet Strachan, Paul DR Johnson, John K Ferguson, Torsten Seemann, Timothy P Stinear, Benjamin P Howden

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | OXFORD UNIV PRESS | Published : 2016

DOI: 10.1093/jac/dkw314

Abstract

BACKGROUND: Enterococcus faecium is a major nosocomial pathogen causing significant morbidity and mortality worldwide. Assessment of E. faecium using MLST to understand the spread of this organism is an important component of hospital infection control measures. Recent studies, however, suggest that MLST might be inadequate for E. faecium surveillance. OBJECTIVES: To use WGS to characterize recently identified vancomycin-resistant E. faecium (VREfm) isolates non-typeable by MLST that appear to be causing a multi-jurisdictional outbreak in Australia. METHODS: Illumina NextSeq and Pacific Biosciences SMRT sequencing platforms were used to determine the genome sequences of 66 non-typeable E. fa..

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University of Melbourne Researchers

Torsten Seemann Author Microbiology and Immunology

Ben Howden Author Microbiology and Immunology

Sarah Baines Author Microbiology and Immunology

Glen Carter Author Microbiology and Immunology

Tim Stinear Author Microbiology and Immunology

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Grants

Awarded by National Health and Medical Research Council, Australia

Funding Acknowledgements

This work was supported by: the Department of Microbiology and Immunology at The University of Melbourne; the National Health and Medical Research Council, Australia (GNT1008549 to T. P. S., GNT1105905 to B. P. H. and GNT1027874 to P. D. R. J., T. P. S. and B. P. H.); and the Department of Health and Human Services, Victoria, Australia.