Journal article
Bladder urine oxygen tension for assessing renal medullary oxygenation in rabbits: Experimental and modeling studies
I Sgouralis, MM Kett, CPC Ow, A Abdelkader, AT Layton, BS Gardiner, DW Smith, YR Lankadeva, RG Evans
American Journal of Physiology Regulatory Integrative and Comparative Physiology | AMER PHYSIOLOGICAL SOC | Published : 2016
Abstract
Oxygen tension (PO2) of urine in the bladder could be used to monitor risk of acute kidney injury if it varies with medullary PO2. Therefore, we examined this relationship and characterized oxygen diffusion across walls of the ureter and bladder in anesthetized rabbits. A computational model was then developed to predict medullary PO2 from bladder urine PO2. Both intravenous infusion of [Phe2,Ile3,Orn8]-vasopressin and infusion of NG-nitro-L-arginine reduced urinary PO2 and medullary PO2 (8-17%), yet had opposite effects on renal blood flow and urine flow. Changes in bladder urine PO2 during these stimuli correlated strongly with changes in medullary PO2 (within-rabbit r2 = 0.87-0.90). Diffe..
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Grants
Awarded by National Institute of Diabetes and Digestive and Kidney Diseases
Funding Acknowledgements
Part of this work was conducted while I. Sgouralis was a Postdoctoral Fellow at the National Institute for Mathematical and Biological Synthesis, an Institute sponsored by the National Science Foundation through NSF Award DBI-1300426, with additional support from The University of Tennessee, Knoxville. Additional support was provided by the National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, via Grant DK-089066 to A. Layton.