Journal article

CRYPTOCOCCAL DISEASE OF THE CNS IN IMMUNOCOMPETENT HOSTS - INFLUENCE OF CRYPTOCOCCAL VARIETY ON CLINICAL MANIFESTATIONS AND OUTCOME

DH MITCHELL, TC SORRELL, AM ALLWORTH, CH HEATH, AR MCGREGOR, K PAPANAOUM, MJ RICHARDS, T GOTTLIEB

CLINICAL INFECTIOUS DISEASES | UNIV CHICAGO PRESS | Published : 1995

Abstract

We performed a retrospective review of cases of cerebral cryptococcosis among patients admitted to 12 Australian teaching hospitals between 1985 and 1992. Of 118 cases identified, 35 occurred in immunocompetent hosts. When cases due to Cryptococcus neoformans variety neoformans were compared with those due to Cryptococcus neoformans variety gattii, we found that the latter tended to occur in healthy hosts whose residence or job was located in a rural area, and cerebral mass lesions and/or hydrocephalus and pulmonary mass lesions were more common. For a subgroup of patients with infection due to C. neoformans variety gattii, multiple enhancing lesions were observed on cerebral computed tomogr..

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University of Melbourne Researchers