Candidemia in nonneutropenic critically ill patients: Risk factors for non-albicans Candida spp.

Abstract

OBJECTIVE: The objective of this study was to determine the clinical features associated with candidemia caused by non-albicans Candida spp. and with potentially fluconazole-resistant Candida spp. (C. glabrata and C. krusei) among candidemic intensive care unit patients. DESIGN: The authors conducted a nationwide prospective cohort study. SETTING: The study was conducted in Australian intensive care units. PATIENTS: All patients with intensive care unit-acquired candidemia over a 3-yr period were included in the study. MEASUREMENTS: Clinical risk factors occurring up to 30 days before candidemia, Candida spp. associated with candidemia, and outcomes were determined. Risk factors associated w..