Journal article
Antifungal therapy and management of complications of cryptococcosis due to Cryptococcus gattii
SCA Chen, TM Korman, MA Slavin, D Marriott, K Byth, N Bak, BJ Currie, K Hajkowicz, CH Heath, S Kidd, WJH McBride, W Meyer, R Murray, EG Playford, TC Sorrell
Clinical Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2013
DOI: 10.1093/cid/cit341
Abstract
Background. We describe antifungal therapy and management of complications due to Cryptococcus gattii infection in 86 Australian patients followed for at least 12 months. Methods. Patient data from culture-confirmed cases (2000-2007) were recorded at diagnosis, 6 weeks, 6 months, and 12 months. Clinical, laboratory, and treatment variables associated with raised intracranial pressure (ICP) and immune reconstitution inflammatory syndrome (IRIS) were determined. Results. Seven of 10 patients with lung infection received amphotericin B (AMB) induction therapy (6 with 5-flucytosine [5-FC] for a median of 2 weeks); median duration of therapy including azole eradication therapy was 41 weeks, with ..
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Funding Acknowledgements
This work was supported in part by Gilead Sciences, Inc. T. C. S. is a Sydney Medical School Foundation Fellow, University of Sydney. The authors thank all hospital laboratory scientists and clinical microbiologists at the study sites for assistance with case identification and referral of CG isolates.