Histologic changes of the iris in the development of angle closure in Chinese eyes

Abstract

PURPOSE: To identify the histologic characteristics of the iris in primary angle closure. METHODS: Iris specimens were obtained by surgical iridectomy in a series of patients in Zhongshan Ophthalmic Center with newly diagnosed acute angle closure (AAC, 12 eyes), fellow eyes of AAC subjects (FAAC, 14 eyes), primary angle closure suspect (PACS, 11 eyes), chronic angle closure glaucoma (CACG, 19 eyes), primary open angle glaucoma (POAG, 7 eyes), and 9 age-matched donated eyes as controls without evidence of glaucoma. Patients with secondary causes for angle closure were excluded. The sirius red polarization method was used to quantify the density of collagen and differentiate the type I and typ..