Journal article

Heritability of central corneal thickness in Chinese: The Guangzhou twin eye study

Yingfeng Zheng, Jian Ge, Guofu Huang, Jian Zhang, Bin Liu, Yoon-Mi Hur, Mingguang He

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2008

Abstract

PURPOSE: To assess the heritability of central corneal thickness (CCT) in Chinese children in a classic twin study. METHODS: Twins aged 8 to 16 years were recruited from the Guangzhou Twin Registry. Pachymetry data were obtained by one operator using the same imaging system. Zygosity was confirmed by genotyping with 16 polymorphic markers in all same-sex twin pairs. The CCT of the right eyes was chosen as the trait of interest in the analysis. Heritability was assessed by a general sex-limitation model, using Mx software (University of Richmond, Virginia). RESULTS: Four hundred forty-nine twin pairs were available for data analyses, including 131 pairs of monozygotic boys (MZM), 44 pairs of ..

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University of Melbourne Researchers

Grants

Awarded by National Basic Research Program of China


Awarded by Guangzhou Science and Technology Development Fund


Awarded by China-Australia NSFC-DEST (the Chinese State National Science Fund Committee-Australian Department of Education, Science and Training)


Awarded by National Ministry of Education


Funding Acknowledgements

Supported by National Basic Research Program of China Grant 2007CB512200, Guangzhou Science and Technology Development Fund Grant 2006Z3-E0061, China-Australia NSFC-DEST (the Chinese State National Science Fund Committee-Australian Department of Education, Science and Training) Special Fund Grant 30371513, and Program for New Century Excellent Talents in University, National Ministry of Education, Grant NCET-06-0720.