Population-based surveillance for scedosporiosis in Australia: Epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection

CH Heath; MA Slavin; TC Sorrell; R Handke; A Harun; M Phillips; Q Nguyen; L Delhaes; D Ellis; W Meyer; SCA Chen; P Collignon; R Benn; I Chambers; N Dennis; D DeWit; J Ferguson; I Gosbell; T Gottlieb; C Halliday; J Holland; A Kesson; R Lawrence; D Marriott; P Newton; P Palasanthrian; R Pickles; B Pritchard; L Tierney; V Tomasotos; R Vaz; K Weeks; B Currie; A Allworth; C Coulter; J Faoagali; B Johnson; D Looke; J McCormack; G Nimmo; G O'Kane; EG Playford; J Robson; K Rowlands; D Shaw; L Cooley; E Cox; A McGregor; C Franklin; T Korman; O Morrissey; D Spelman; B Speed; P Boan; J Dyer; D Gardam; D McLennan; R Murray; T Pryce

Journal article

Population-based surveillance for scedosporiosis in Australia: Epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection

CH Heath, MA Slavin, TC Sorrell, R Handke, A Harun, M Phillips, Q Nguyen, L Delhaes, D Ellis, W Meyer, SCA Chen, P Collignon, R Benn, I Chambers, N Dennis, D DeWit, J Ferguson, I Gosbell, T Gottlieb, C Halliday Show all

Clinical Microbiology and Infection | ELSEVIER SCI LTD | Published : 2009

DOI: 10.1111/j.1469-0691.2009.02802.x

Abstract

Australia-wide population-based surveillance for scedosporiosis identified 180 cases, with 118 (65.6%) cases of colonization and 62 (34.4%) cases of infection. Predisposing factors for isolation of Scedosporium spp. included chronic lung disease in 37.8% and malignancy in 21.7% of cases. Predictors of invasive disease (n = 62) included haematological stem cell transplantation (n = 7), leukaemia (n = 16) and diabetes mellitus (n = 8). Of 183 phenotypically-speciated isolates, 75 (41%) were Scedosporium prolificans (risk factors: haematologic cancer (n = 17), neutropaenia (n = 14)) and 108 (59%) had Scedosporium apiospermum/Pseudallescheria boydii phenotype [risk factor: diabetes (n = 15)]. Sc..

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