Skeletal muscle-specific overexpression of IGFBP-2 promotes a slower muscle phenotype in healthy but not dystrophic mdx mice and does not affect the dystrophic pathology
Kristy Swiderski, Karen Janet Bernice Martins, Annabel Chee, Jennifer Trieu, Timur Naim, Stefan Martin Gehrig, Dale Michael Baum, Julia Brenmoehl, Luong Chau, Rene Koopman, Paul Gregorevic, Friedrich Metzger, Andreas Hoeflich, Gordon Stuart Lynch
Growth Hormone & IGF Research | CHURCHILL LIVINGSTONE | Published : 2016
This project was supported by the Muscular Dystrophy Association, U.S.A. (GSL). KS was supported by an Early Career Fellowship from the National Health & Medical Research Council of Australia (NH&MRC). The authors thank Professor Jeffrey S. Chamberlain (The University of Washington, Seattle, USA) for provision of the rAAV-CMV-MCS expression vector, and Dr. Hongwei Qian (Baker IDI Heart & Diabetes Institute) for assistance with manufacture of recombinant AAV vectors. The Baker IDI Heart & Diabetes Institute is supported in part by the Operational Infrastructure Support Program of the Victorian Government.