Journal article
Serial Diffusion Tensor Imaging of the Optic Radiations after Acute Optic Neuritis
SC Kolbe, AVD Walt, H Butzkueven, A Klistorner, GF Egan, TJ Kilpatrick
Journal of Ophthalmology | HINDAWI LTD | Published : 2016
DOI: 10.1155/2016/2764538
Abstract
Previous studies have reported diffusion tensor imaging (DTI) changes within the optic radiations of patients after optic neuritis (ON). We aimed to study optic radiation DTI changes over 12 months following acute ON and to study correlations between DTI parameters and damage to the optic nerve and primary visual cortex (V1). We measured DTI parameters [fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD)] from the optic radiations of 38 acute ON patients at presentation and 6 and 12 months after acute ON. In addition, we measured retinal nerve fibre layer thickness, visual evoked potential amplitude, optic radiation lesion load, and V1 thick..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the Australian National Health and Medical Research Council (NHMRC) Project Grant (APP1009757, Gary F. Egan, Helmut Butzkueven and Alexander Klistorner), NHMRC Peter Doherty Early Career Fellowship (APP1054147, Scott C. Kolbe), MS Research Australia Postdoctoral Fellowship (0030, Scott C. Kolbe), a National MS Society of the US Project Grant (RG4211A4/2 2010, Trevor J. Kilpatrick), the CHDI Foundation Inc., New York, USA (A-3433, Gary F. Egan), with computational resources supported by a merit based Resource Allocation Scheme Grant from the Victorian Life Sciences Computing Initiative (no. 1529, Scott C. Kolbe). The authors thank Mr. Michael Kean and the Murdoch Children's Research Institute Research MRI facility for assistance with MRI scanning and Ms. Stephanie Tsonsis at the Royal Victorian Eye and Ear Hospital for assistance with mfVEP and OCT testing. They also thank all the participants in the study for their support of the research.