Oligometastatic bone disease in prostate cancer patients treated on the TROG 03.04 RADAR trial
Swetha Sridharan, Allison Steigler, Nigel A Spry, David Joseph, David S Lamb, John H Matthews, Chris Atkinson, Keen-Hun Tai, Gillian Duchesne, David Christie, John Attia, Elizabeth G Holliday, James W Denham
RADIOTHERAPY AND ONCOLOGY | ELSEVIER IRELAND LTD | Published : 2016
BACKGROUND: It remains unclear whether eradication of oligometastases by stereotactic body radiation therapy or other means will result in cure or prolongation of survival in some cases, or merely provide palliation. We address this issue with prospectively collected progression and treatment data from the TROG 03.04 RADAR randomised controlled trial for men with locally advanced prostate cancer (PC). METHODS: Three Fine and Gray competing risk survival models with time-dependent covariates were used to determine whether metastatic progression status at first diagnosis of bony metastases, i.e. number of bony sites involved and presence of prior or simultaneous other sites of progression, imp..View full abstract
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Awarded by National Health and Medical Research Council of Australia (NHMRC)
This study received support from the National Health and Medical Research Council of Australia (NHMRC) (Project Application IDs 300705, 455521 and 1099149) and Calvary Health Care (Calvary Mater Newcastle Radiation Oncology Fund).