Journal article

Dynamic change of neutrophil to lymphocyte ratio and hemorrhagic transformation after thrombolysis in stroke

Zhiliang Guo, Shuhong Yu, Lulu Xiao, Xin Chen, Ruidong Ye, Ping Zheng, Qiliang Dai, Wen Sun, Changsheng Zhou, Shuiping Wang, Wusheng Zhu, Xinfeng Liu

JOURNAL OF NEUROINFLAMMATION | BIOMED CENTRAL LTD | Published : 2016

Abstract

BACKGROUND: The neutrophil to lymphocyte ratio (NLR) has been shown to predict short- and long-term outcomes in ischemic stroke patients. We sought to explore the temporal profile of the plasma NLR in stroke patients treated with intravenous thrombolysis (IVT) and its relationship with intracranial bleeding complications after thrombolysis. METHODS: A total of 189 ischemic stroke patients were prospectively enrolled. Blood samples for leukocyte, neutrophil, and lymphocyte counts were obtained at admission and at 3-6, 12-18, and 36-48 h after IVT. Head CT was performed on admission and repeated after 36-48 h, and a CT scan was done immediately in case of clinical worsening. Hemorrhagic events..

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Grants

Awarded by National Natural Science Foundation of China


Funding Acknowledgements

This study was supported in part by the National Natural Science Foundation of China (Nos. 81171099, 81501193, and 81471182). The collection of this study was supported in part by the National Natural Science Foundation of China (Nos. 81171099, 81501193, and 81471182). The design of the study and analysis and interpretation of data and writing the manuscript was supported by the National Natural Science Foundation of China (Nos. 81171099 and 81501193).