Journal article
Younger age-at-diagnosis for familial malignant testicular germ cell tumor
PL Mai, BE Chen, K Tucker, M Friedlander, KA Phillips, D Hogg, MAS Jewett, I Bodrogi, L Geczi, E Olah, K Heimdal, SD Fosså, KL Nathanson, L Korde, DF Easton, D Dudakia, R Huddart, MR Stratton, DT Bishop, EA Rapley Show all
Familial Cancer | SPRINGER | Published : 2009
Abstract
One of the clinical hallmarks of hereditary cancer susceptibility disorders is a younger-than-usual age at diagnosis. Familial aggregation of testicular germ cell tumor (TGCT) has been reported, but data on whether familial TGCT cases are diagnosed at an earlier age are inconclusive. Here we compared the age at diagnosis of familial TGCT cases with that of population cases in several countries. Familial TGCT is defined as affected individuals from families with ≥2 cases of TGCT. Age at diagnosis of familial cases from the United States, Canada, United Kingdom, Australia and New Zealand, Norway, and Hungary was compared to cases identified in population-based cancer registries from the respec..
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Awarded by National Institutes of Health
Funding Acknowledgements
We would like to thank Dr. Parry Guilford for his contribution to the familial TGCT cases. We also thank Istvan Gaudi (Cancer Registry of National Institute of Oncology, Budapest, Hungary) and Sue Westlake (Social & Health Analysis & Reporting Division, Office for National Statistics, UK) for their contribution from the cancer registries. This research was funded in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, and supported by contracts N02-CP-11019 and N02-CP-65504 with Westat, Incorporated. The authors have no conflict of interest or financial disclosures to report.