Journal article
The international testicular cancer linkage consortium: A clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred
PL Mai, M Friedlander, K Tucker, KA Phillips, D Hogg, MAS Jewett, R Lohynska, G Daugaard, S Richard, C Bonaïti-Pellié, A Heidenreich, P Albers, I Bodrogi, L Geczi, E Olah, PA Daly, P Guilford, SD Fosså, K Heimdal, L Liubchenko Show all
Urologic Oncology Seminars and Original Investigations | ELSEVIER SCIENCE INC | Published : 2010
Abstract
Objectives: Familial aggregation of testicular germ cell tumor (TGCT) has been reported, but it is unclear if familial TGCT represents a unique entity with distinct clinicopathologic characteristics. Here we describe a collection of familial TGCT cases from an international consortium, in an effort to elucidate any clinical characteristics that are specific to this population. Materials and methods: Families with ≥2 cases of TGCT enrolled at 18 of the sites participating in the International Testicular Cancer Linkage Consortium were included. We analyzed clinicopathologic characteristics of 985 cases from 461 families. Results: A majority (88.5%) of families had only 2 cases of TGCT. Men wit..
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Awarded by National Institutes of Health
Funding Acknowledgements
This research was funded in part by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, and supported by contracts N02-CP-11019 and N02-CP-65504 with Westat, Inc. Other funding includes grant R01 CA114478 (K.L.N.).