Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma
Ugur Eskiocak, Vijayashree Ramesh, Jennifer G Gill, Zhiyu Zhao, Stacy W Yuan, Meng Wang, Travis Vandergriff, Mark Shackleton, Elsa Quintana, Timothy M Johnson, Ralph J DeBerardinis, Sean J Morrison
Nature Communications | NATURE PUBLISHING GROUP | Published : 2016
Awarded by National Institutes of Health
Awarded by NIH
S.J.M. is a Howard Hughes Medical Institute (HHMI) Investigator, the Mary McDermott Cook Chair in Pediatric Genetics, the director of the Hamon Laboratory for Stem Cells and Cancer, and a Cancer Prevention and Research Institute of Texas Scholar. In addition to support from HHMI and CPRIT to S.J.M., this work was also supported by the National Institutes of Health (CA157996) to R.J.D. M.W. was supported by a British Society for Haematology Scientific Fellowship. We thank the Department of Obstetrics and Gynecology for providing umbilical cord blood (a service supported, in part, through NIH P01HD11149) and to the Michigan Biobank (supported in part by the Lewis and Lillian Becker and Howard Cooper Funds). We thank N. Meireles and A. Durham for tissue procurement and clinical data management; J. Peyer and S. Mann for technical support; K. Correll and M. Gross for mouse colony management; N. Loof and the Moody Foundation Flow Cytometry Facility; Z. Hu for digitoxin pharmacokinetics; K. Phelps for live-cell imaging and J. Shelton for histology.