Homeobox gene TGIF-1 is increased in placental endothelial cells of human fetal growth restriction
Tilini Gunatillake, Hannah EJ Yong, Caroline E Dunk, Rosemary J Keogh, Anthony J Borg, Judith E Cartwright, Guy S Whitley, Padma Murthi
REPRODUCTION | BIOSCIENTIFICA LTD | Published : 2016
Aberrant placental angiogenesis is associated with fetal growth restriction (FGR). In mice, targeted disruption of the homeobox gene, transforming growth β-induced factor (Tgif-1), which is also a transcription factor, causes defective placental vascularisation. Nevertheless, the role of TGIF-1 in human placental angiogenesis is unclear. We have previously reported increased TGIF-1 expression in human FGR placentae and demonstrated localisation of TGIF-1 protein in placental endothelial cells (ECs). However, its functional role remains to be investigated. In this study, we aimed to specifically compare TGIF-1 mRNA expression in placental ECs isolated from human FGR-affected pregnancies with ..View full abstract
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Awarded by Australian National Health and Medical Research Council (NHMRC)
Awarded by Medical Research Council
This work was supported by the Australian National Health and Medical Research Council (NHMRC project grant #509140) to Dr P Murthi.