Interrupting prolonged sitting with brief bouts of light walking or simple resistance activities reduces resting blood pressure and plasma noradrenaline in type 2 diabetes

Abstract

Objective: Prolonged sitting is increasingly recognized as a ubiquitous cardiometabolic risk factor, possibly distinct from lack of physical exercise. We examined whether interrupting prolonged sitting with brief bouts of lightintensity activity reduced blood pressure (BP) and plasma noradrenaline in type 2 diabetes (T2D). Methods: In a randomized crossover trial, 24 inactive overweight/obese adults with T2D (14 men; mean±SD; 62±6 years) consumed standardized meals during 3-8h conditions: uninterrupted sitting (SIT); sittingRhalf-hourly bouts of walking (3.2 km/h for 3-min) (light-intensity walking); and sittingRhalf-hourly bouts of simple resistance activities for 3 min (SRAs), each separat..