Journal article

Interrupting prolonged sitting with brief bouts of light walking or simple resistance activities reduces resting blood pressure and plasma noradrenaline in type 2 diabetes

Paddy C Dempsey, Julian W Sacre, Robyn N Larsen, Nora E Straznicky, Parneet Sethi, Neale D Cohen, Ester Cerin, Gavin W Lambert, Neville Owen, Bronwyn A Kingwell, David W Dunstan



OBJECTIVE: Prolonged sitting is increasingly recognized as a ubiquitous cardiometabolic risk factor, possibly distinct from lack of physical exercise. We examined whether interrupting prolonged sitting with brief bouts of light-intensity activity reduced blood pressure (BP) and plasma noradrenaline in type 2 diabetes (T2D). METHODS: In a randomized crossover trial, 24 inactive overweight/obese adults with T2D (14 men; mean ± SD; 62 ± 6 years) consumed standardized meals during 3 × 8 h conditions: uninterrupted sitting (SIT); sitting + half-hourly bouts of walking (3.2 km/h for 3-min) (light-intensity walking); and sitting + half-hourly bouts of simple resistance activities for 3 min (SRAs), ..

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Awarded by NHMRC

Awarded by ARC Future Fellowship

Funding Acknowledgements

This study was funded by NHMRC project grant no. 1081734 and the Victorian Government OIS scheme. PCD is supported by an Australian Postgraduate Award. G.W.L., N.O., B.A.K., J.W.S. and D.W.D. are supported by the NHMRC Fellowships scheme. E.C. is supported by an ARC Future Fellowship no. FT140100085.