Journal article

Open-Label Study of Absorption and Clearance of 1% Voriconazole Eye Drops

Chin Fen Neoh, Lok Leung, Elsie Chan, Daoud Al-Badriyeh, Robert O Fullinfaw, Vishal Jhanji, Rasik B Vajpayee, Geoffrey E Davies, Kay Stewart, David CM Kong

Antimicrobial Agents and Chemotherapy | AMER SOC MICROBIOLOGY | Published : 2016


Twenty participants undergoing elective cataract surgery received 1% voriconazole eye drops (1 drop per eye) either 20, 40, 60, or 80 min before surgery. Median voriconazole concentrations of 1.9 to 3.2 mg/liter in aqueous humor samples were attained over the first 80 min, which were higher than in vitro MIC90 values for typical fungi that cause keratitis.