Journal article
Open-label study of absorption and clearance of 1% voriconazole eye drops
CF Neoh, L Leung, E Chan, D Al-Badriyeh, RO Fullinfaw, V Jhanji, RB Vajpayee, GE Davies, K Stewart, DCM Kong
Antimicrobial Agents and Chemotherapy | AMER SOC MICROBIOLOGY | Published : 2016
DOI: 10.1128/AAC.00683-16
Abstract
Twenty participants undergoing elective cataract surgery received 1% voriconazole eye drops (1 drop per eye) either 20, 40, 60, or 80 min before surgery. Median voriconazole concentrations of 1.9 to 3.2 mg/liter in aqueous humor samples were attained over the first 80 min, which were higher than in vitro MIC90 values for typical fungi that cause keratitis.