Journal article

Olfactory sulcus morphology in patients with current and past major depression

Tsutomu Takahashi, Yumiko Nishikawa, Murat Yucel, Sarah Whittle, Valentina Lorenzetti, Mark Walterfang, Daiki Sasabayashi, Michio Suzuki, Christos Pantelis, Nicholas B Allen



Olfactory deficits have been reported in major depressive disorder (MDD). However, it remains largely unknown whether MDD is associated with abnormalities in olfactory sulcus morphology, a potential marker of olfactory system development. This magnetic resonance imaging study investigated the length and depth of the olfactory sulcus in 29 currently depressed patients, 27 remitted depressed patients, and 33 age- and gender-matched healthy control subjects. Both current and remitted MDD patients had significantly shallower olfactory sulci bilaterally as compared with controls. Only for male subjects, the right olfactory sulcus was significantly shorter in remitted MDD patients than in controls..

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Awarded by Japanese Society for the Promotion of Science

Awarded by National Health and Medical Research Council of Australia (NHMRC)

Awarded by NHMRC

Funding Acknowledgements

This research was supported in part by Grants-in-Aid for Scientific Research (C) (No. 26461739) and Grants-in-Aid for Scientific Research (B) (No. 24390281) from the Japanese Society for the Promotion of Science, and Health and Labour Sciences Research Grants for Comprehensive Research on Persons with Disabilities from Japan Agency for Medical Research and Development (AMED). MY was supported by a National Health and Medical Research Council of Australia (NHMRC) Fellowship (#APP1021973). SW was supported by a NHMRC Career Development Fellowship (ID: 1007716). CP was supported by a NHMRC Senior Principal Research Fellowship (ID: 628386 and 1105825). None of the funding sources had any role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. Neuroimaging analysis was facilitated by the Neuropsychiatry Imaging Laboratory at the Melbourne Neuropsychiatry Centre and supported by Neurosciences Victoria. The authors thank Ms. Orli Schwartz and Ms. Diana Maud for recruitment and assessment of the participants.