Journal article
Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling
MAR Ferreira, R Jansen, G Willemsen, B Penninx, LM Bain, CT Vicente, JA Revez, MC Matheson, J Hui, JY Tung, S Baltic, P Le Souëf, GW Montgomery, NG Martin, CF Robertson, A James, PJ Thompson, DI Boomsma, JL Hopper, DA Hinds Show all
Journal of Allergy and Clinical Immunology | MOSBY-ELSEVIER | Published : 2017
Abstract
Background Hundreds of genetic variants are thought to contribute to variation in asthma risk by modulating gene expression. Methods that increase the power of genome-wide association studies (GWASs) to identify risk-associated variants are needed. Objective We sought to develop a method that aggregates the evidence for association with disease risk across expression quantitative trait loci (eQTLs) of a gene and use this approach to identify asthma risk genes. Methods We developed a gene-based test and software package called EUGENE that (1) is applicable to GWAS summary statistics; (2) considers both cis- and trans-eQTLs; (3) incorporates eQTLs identified in different tissues; and (4) uses ..
View full abstractGrants
Awarded by National Institutes of Health
Funding Acknowledgements
Supported in part by the National Human Genome Research Institute of the National Institutes of Health (R44HG006981) and the National Health and Medical Research Council of Australia (613627 and APP1036550).