Journal article
Associations of neighborhood environment with brain imaging outcomes in the Australian Imaging, Biomarkers and Lifestyle cohort
E Cerin, SR Rainey-Smith, D Ames, NT Lautenschlager, SL Macaulay, C Fowler, JS Robertson, CC Rowe, P Maruff, RN Martins, CL Masters, KA Ellis
Alzheimer S and Dementia | WILEY | Published : 2017
Abstract
Introduction “Walkable” neighborhoods offer older adults opportunities for activities that may benefit cognition-related biological mechanisms. These have not previously been examined in this context. Methods We objectively assessed neighborhood walkability for participants (n = 146) from the Australian Imaging, Biomarkers and Lifestyle study with apolipoprotein E (APOE) genotype and two 18-month-apart brain volumetric and/or amyloid β burden assessments. Linear mixed models estimated associations of neighborhood walkability with levels and changes in brain imaging outcomes, the moderating effect of APOE ε4 status, and the extent to which associations were explained by physical activity. Res..
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Awarded by Science and Industry Endowment Fund
Funding Acknowledgements
Ester Cerin was supported by an Australian Research Council Future Fellowship (FT140100085). Geocoding for this study was supported by a grant from the Centre for Physical Activity and Nutrition Research, Deakin University. Funding for the AIBL study was provided by the CSIRO Flagship Collaboration Fund and the Science and Industry Endowment Fund (SIEF) in partnership with Edith Cowan University (ECU), The Florey Institute of Neuroscience and Mental Health, Alzheimer's Australia (AA), National Ageing Research Institute (NARI), Austin Health, CogState Ltd., Hollywood Private Hospital, and Sir Charles Gairdner Hospital. The study also receives funding from the National Health and Medical Research Council (NHMRC), the Dementia Collaborative Research Centres program (DCRC2) and the McCusker Alzheimer's Research Foundation, and Operational Infrastructure Support from the Government of Victoria.