Comparative Plasma and Cerebrospinal Fluid Pharmacokinetics of Paracetamol After Intravenous and Oral Administration
Roger A Langford, Malcolm Hogg, Andrew R Bjorksten, Daryl L Williams, Kate Leslie, Kris Jamsen, Carl Kirkpatrick
ANESTHESIA AND ANALGESIA | LIPPINCOTT WILLIAMS & WILKINS | Published : 2016
BACKGROUND: We compared plasma and cerebrospinal fluid (CSF) pharmacokinetics of paracetamol after intravenous (IV) and oral administration to determine dosing regimens that optimize CSF concentrations. METHODS: Twenty-one adult patients were assigned randomly to 1 g IV, 1 g oral or 1.5 g oral paracetamol. An IV cannula and lumbar intrathecal catheter were used to sample venous blood and CSF, respectively, over 6 hours. The plasma and CSF maximum concentrations (Cmax), times to maximum concentrations (Tmax), and area under the plasma and CSF concentration-time curves (AUCs) were calculated using noncompartmental techniques. Significance was defined by P < .0167 (Bonferroni correction for 3 c..View full abstract
This study was funded by the Department of Anaesthesia and Pain Management, Royal Melbourne Hospital.