Cancer mortality in workers exposed to phenoxy herbicides, chlorophenols, and dioxins: An expanded and updated International Cohort Study

M Kogevinas; H Becher; T Benn; PA Bertazzi; P Boffetta; HB Bueno-de-Mesquita; D Coggon; D Colin; D Flesch-Janys; M Fingerhut; L Green; T Kauppinen; M Littorin; E Lynge; JD Mathews; M Neuberger; N Pearce; R Saracci

Journal article

Cancer mortality in workers exposed to phenoxy herbicides, chlorophenols, and dioxins: An expanded and updated International Cohort Study

M Kogevinas, H Becher, T Benn, PA Bertazzi, P Boffetta, HB Bueno-de-Mesquita, D Coggon, D Colin, D Flesch-Janys, M Fingerhut, L Green, T Kauppinen, M Littorin, E Lynge, JD Mathews, M Neuberger, N Pearce, R Saracci

American Journal of Epidemiology | JOHNS HOPKINS UNIV SCHOOL HYGIENE PUB HEALTH | Published : 1997

DOI: 10.1093/oxfordjournals.aje.a009069

Abstract

The authors examined cancer mortality in a historical cohort study of 21,863 male and female workers in 36 cohorts exposed to phenoxy herbicides, chlorophenols, and dioxins in 12 countries. Subjects in this updated and expanded multinational study coordinated by the International Agency for Research on Cancer were followed from 1939 to 1992. Exposure was reconstructed using job records, company exposure questionnaires, and serum and adipose tissue dioxin levels. Among workers exposed to phenoxy herbicides contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or higher chlorinated dioxins, mortality from soft-tissue sarcoma (6 deaths; standardized mortality ratio (SMR) = 2.03, 95% conf..

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