Journal article

IMMUNE-COMPLEXES AND ROSS RIVER VIRUS-DISEASE (EPIDEMIC POLYARTHRITIS)

JRE FRASER, AL CUNNINGHAM, JD MATHEWS, A RIGLAR

RHEUMATOLOGY INTERNATIONAL | SPRINGER VERLAG | Published : 1988

Abstract

Immune complexes were sought in serum and synovial fluid in Ross River virus disease (epidemic polyarthritis). Multiple samples from 15 patients showing varied degrees of disease activity over a 3 month period were analysed for their content of complement components C3 and C4, and for C1q solid-phase and Raji cell binding activity. Levels of C3 and C1q binding activity were normal. C4 and Raji cell binding activity were normal except for three high levels of Raji cell binding, of which two were accompanied by low levels of C4, with normal C3 and C1q binding. Synovial fluid showed anomalous Raji cell reactivity of uncertain significance. Conglutinin solid-phase binding activity and IgG rheuma..

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