Journal article

GENETICS AND ALCOHOL - IMPLICATIONS FOR HUMAN-DISEASE

JD MATHEWS

AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE | ADIS PRESS AUSTRALASIA P/L | Published : 1981

Abstract

Genes influencing alcohol consumption may act via neurohormonal mechanisms affecting personality and behaviour. The higher average consumption of alcohol in males may reflect the influence of androgens on acetaldehyde metabolism, and higher levels of blood acetaldehyde may be markers of the addictive diathesis. At a given consumption of alcohol, females are more susceptible than males to organ damage; this increased susceptibility may also be due to the effects of sex hormones on the metabolism of alcohol and acetaldehyde. Genetic defects in thiamine-requiring enzymes may predispose to the neurological complications of alcohol abuse, and HLA alleles may predispose to cirrhosis, pancreatitis ..

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