The impact of HLA-G 3 ' UTR variants and sHLA-G on risk and clinical correlates of schizophrenia
Ashwini Rajasekaran, Venkataram Shivakumar, Sunil V Kalmady, Janardhanan C Narayanaswamy, Manjula Subbana, Deepthi Venugopal, Anekal C Amaresha, Ganesan Venkatasubramanian, Michael Berk, Monojit Debnath
HUMAN IMMUNOLOGY | ELSEVIER SCIENCE INC | Published : 2016
The Major Histocompatibility Complex (MHC)/Human Leukocyte Antigen (HLA) is known to influence the pathogenesis of several complex human diseases resulting from gene-environmental interactions. Recently, it has emerged as one of the risk determinants of schizophrenia. The HLA-G protein (a non-classical MHC class I molecule), encoded by the HLA-G gene, is shown to play important role in embryonic development. Importantly, its genetic variations and aberrant expression have been implicated in pregnancy complications like preeclampsia, inflammation, and autoimmunity. Converging evidence implicates these phenomena as risk mechanisms of schizophrenia. However, the functional implications of HLA-G..View full abstract
Awarded by Department of Biotechnology, Government of India
Awarded by Wellcome Trust/DBT India Alliance
Awarded by NHMRC
AR is supported by DST-INSPIRE fellowship. VS & MS are supported by the CEIB Programme Support Grant, Department of Biotechnology, Government of India (BT/PR5322/COE/34/8/2012). SVK & ACA are supported by the Wellcome Trust/DBT India Alliance (500236/Z/11/Z). DV is supported by UGC Fellowship. MB is currently supported by a NHMRC Senior Principal Research Fellowship 1059660.