Normal saline versus lower-chloride solutions for kidney transplantation
Susan Wan, Matthew A Roberts, Peter Mount
COCHRANE DATABASE OF SYSTEMATIC REVIEWS | WILEY | Published : 2016
BACKGROUND: The ideal intravenous fluid for kidney transplantation has not been defined, despite the common use of normal saline during the peri-operative period. The high chloride content of normal saline is associated with an increased risk of hyperchloraemic metabolic acidosis, which may in turn increase the risk of hyperkalaemia and delayed graft function. Balanced electrolyte solutions have a lower chloride content which may decrease this risk and avoid the need for dialysis due to hyperkalaemia in the immediate post-transplant period. Randomised controlled trials (RCTs) addressing this issue have used biochemical outcomes to compare fluids and have been underpowered to address patient-..View full abstract
The authors wish to thank Dr Laurence Weinberg for reviewing and assisting with the manuscript. We also acknowledge the support of the Department of Nephrology at the Austin Hospital, Melbourne, as well as the assistance of the Cochrane Kidney and Transplant Editors and referees, and the Information Specialist.