Journal article

Role of genetic susceptibility variants in predicting clinical course in multiple sclerosis: a cohort study

Gongbu Pan, Steve Simpson, Ingrid van der Mei, Jac C Charlesworth, Robyn Lucas, Anne-Louise Ponsonby, Yuan Zhou, Feitong Wu, Bruce V Taylor

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | BMJ PUBLISHING GROUP | Published : 2016

Abstract

BACKGROUND: The genetic drivers of multiple sclerosis (MS) clinical course are essentially unknown with limited data arising from severity and clinical phenotype analyses in genome-wide association studies. METHODS: Prospective cohort study of 127 first demyelinating events with genotype data, where 116 MS risk-associated single nucleotide polymorphisms (SNPs) were assessed as predictors of conversion to MS, relapse and annualised disability progression (Expanded Disability Status Scale, EDSS) up to 5-year review (ΔEDSS). Survival analysis was used to test for predictors of MS and relapse, and linear regression for disability progression. The top 7 SNPs predicting MS/relapse and disability p..

View full abstract