Journal article
Role of genetic susceptibility variants in predicting clinical course in multiple sclerosis: A cohort study
G Pan, S Simpson, I van der Mei, JC Charlesworth, R Lucas, AL Ponsonby, Y Zhou, F Wu, BV Taylor, K Dear, T Dwyer, L Blizzard, S Broadley, T Kilpatrick, D Williams, J Lechner-Scott, C Shaw, C Chapman, A Coulthard, P Valery
Journal of Neurology Neurosurgery and Psychiatry | BMJ PUBLISHING GROUP | Published : 2016
Abstract
Background The genetic drivers of multiple sclerosis (MS) clinical course are essentially unknown with limited data arising from severity and clinical phenotype analyses in genome-wide association studies. Methods Prospective cohort study of 127 first demyelinating events with genotype data, where 116 MS risk-Associated single nucleotide polymorphisms (SNPs) were assessed as predictors of conversion to MS, relapse and annualised disability progression (Expanded Disability Status Scale, EDSS) up to 5-year review (I "EDSS). Survival analysis was used to test for predictors of MS and relapse, and linear regression for disability progression. The top 7 SNPs predicting MS/relapse and disability p..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The AusLong cohort study was supported by the National Health and Medical Research Council of Australia (Grant reference number: 54922).